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1

Does EMA or FDA have a preferred method for dealing with missing data for when companies submit new drugs for approval?

Jonathan Bartlett

2278

2

I am planning a placebo-controlled trial in a chronic pain condition and know that I will get a high percentage of patients dropping out, but don't yet know if it will be at random or related to the test article.

2061

3

If I have fully observed baseline covariates but missing response and the reponse is only measured at endpoint, is it worthwhile to do a multiple imputation?

1992

4

What should I write in my analysis plan about the main analysis I'm going to use when I only know there're missing data but nothing else, such as % of missing or the missing mechanism, etc?

2167

5

When would you advise using LOCF (last observation carried forward) in the analysis of a clinical trial?

2036

6

What is the difference between last observation carried forward, reporting of as-observed data, and how inferior are these analyses to intent-to-treat analysis?

2656