This data set is one of only a few publicly available data sets that can be used to demonstrate methods for handling missing data where a continuous outcome is measured repeatedly.
Original data are from an antidepressant clinical trial with four treatments; two doses of an experimental medication, a positive control, and placebo.
Hamilton 17-item rating scale for depression (HAMD17) was observed at baseline and weeks 1, 2, 4, 6, and 8.
To mask the real data Week-8 observations were removed.
Two arms were created; the original placebo arm and a “drug arm” created by randomly selecting patients from the three non-placebo arms.
[Original data: Goldstein, Lu, Detke, Wiltse, Mallinckrodt, Demitrack. Duloxetine in the treatment of depression: a double-blind placebo-controlled comparison with paroxetine. J Clin
Psychopharmacol 2004;24: 389-399.]
The data set can be downloaded here MBSW2011_example
Name of the SAS data set is “Chapter15 example.sas7bdat”.